The Skeptologists is a new reality TV show that is currently in production. At this stage it's only a pilot episode being made on spec but I'd be surprised if it wasn't picked up. The show takes a decidedly skeptical stance so it might struggle to find a primetime slot (which are notoriously biased toward more credulous shows). Still, if it's done well I think this could be another Mythbusters.
Hosted by Brian Dunning, the impressive cast is made up of Phil Plait (badastronomy.com), Michael Shermer (The Skeptic Society), Yau-Man Chan (Chief Technology Officer at UC Berkeley College of Chemistry and contestant on Survivor: Fiji), Kirsten Sanford (neurophysiologist and host of This Week in Science), Mark Edward (mentalist), and Steven Novella (medical doctor and host of The Skeptic’s Guide to the Universe).